WELCOME TO MASTEN RESEARCH
Revolutionizing Cancer with Smart Vaccines
World-Record Breaking Treatment
Interactive Smart Cancer Vaccine
Click each step to explore the cellular mechanisms in detail
Smart Vaccine Injection
Precision-engineered vaccine particles containing tumor-specific antigens and immunomodulatory adjuvants are delivered to activate the immune system.
Click to explore cellular detailsDendritic Cell Activation
Professional antigen-presenting cells capture vaccine components, process antigens, and undergo maturation to become powerful immune educators.
Click to see antigen processingT Cell Stimulation
Activated dendritic cells present processed antigens to naive T cells, triggering their differentiation into cytotoxic CD8+ T lymphocytes.
Click to view T cell activationTumor Cell Recognition
Activated cytotoxic T cells patrol the body, recognize cancer cells through MHC-I antigen presentation, and form immunological synapses.
Click to see targeting mechanismTumor Cell Elimination
T cells release cytotoxic granules containing perforin and granzymes, inducing targeted apoptosis while preserving healthy tissue.
Click to explore cell death pathwayTreatment Comparison
Traditional Chemotherapy
- ❌ Attacks both cancer and healthy cells
- ❌ Severe side effects and toxicity
- ❌ Weakens immune system
- ❌ Drug resistance development
- ❌ Limited long-term protection
Smart Immunomodulatory Vaccine
- ✅ Precisely targets only cancer cells
- ✅ Minimal side effects
- ✅ Strengthens immune system
- ✅ Creates immunological memory
- ✅ Long-term cancer surveillance
Smart Vaccine Injection - Microscopic View
Mechanism of Action:
The smart vaccine contains engineered nanoparticles loaded with tumor-associated antigens (TAAs) and immunomodulatory adjuvants. These particles are designed to:
- Target specific immune cells through surface receptors
- Deliver antigens in a controlled, sustained manner
- Activate danger signals to enhance immune recognition
- Cross biological barriers to reach lymphoid organs
Dendritic Cell Activation - Cellular Detail
Antigen Processing Pathway:
Dendritic cells are the most potent antigen-presenting cells. Upon vaccine uptake, they:
- Internalize vaccine particles through endocytosis
- Process antigens in specialized compartments
- Load peptide fragments onto MHC molecules
- Migrate to lymph nodes for T cell education
- Upregulate co-stimulatory molecules (CD80, CD86)
T Cell Activation - Immunological Synapse
T Cell Activation Signals:
T cell activation requires three critical signals:
- Signal 1: TCR recognition of peptide-MHC complex
- Signal 2: Co-stimulatory molecules (CD28-CD80/86)
- Signal 3: Cytokine signals (IL-2, IL-12, IFN-α)
This leads to T cell proliferation, differentiation into cytotoxic effectors, and memory formation.
Tumor Recognition - Molecular Targeting
Molecular Recognition Process:
Cytotoxic T cells identify cancer cells through:
- MHC-I Recognition: TCR binds to tumor peptides on MHC-I
- Co-receptor Binding: CD8 stabilizes the interaction
- Adhesion Molecules: LFA-1/ICAM-1 strengthen cell contact
- Cytotoxic Synapse: Specialized contact zone formation
This ensures specific targeting of cancer cells while sparing healthy tissue.
Cancer Cell Destruction - Apoptotic Pathway
Cytotoxic Mechanisms:
T cells eliminate cancer cells through two main pathways:
- Perforin/Granzyme: Creates pores in target cell membrane, delivers pro-apoptotic enzymes
- Fas/FasL: Death receptor-mediated apoptosis signaling
- TNF-α: Tumor necrosis factor induces cell death
- IFN-γ: Enhances antigen presentation and immune activation
This results in controlled apoptosis, preventing inflammation while eliminating malignant cells.
This information is for research purposes
Advanced Cancer Research
Masten Research conducts innovative research in cancer treatment using immunomodulation and genetic approaches. Our clinical studies aim to offer new treatment options to patients through scientifically based experimental methods.

500+ Patients
Joined the Research
15+ Protocols
Active Research
With Scientific Research and Ethical Values
We are a research center that develops innovative approaches in cancer treatment and offers promising solutions by prioritizing patient safety.
Our Mission and Vision
Masten Research is a research center conducting studies to international standards in the field of cancer research. By focusing on immunomodulation, genetic approaches, and personalized treatment protocols, we aim to offer patients promising experimental treatment options.
Our research is conducted within strict ethical rules and in accordance with international clinical research standards. We focus on determining the most appropriate research protocol by making individual evaluations for each patient.
Our multidisciplinary team consists of expert researchers in oncology, immunology, genetics, and biomedical engineering. With a principle of continuous education and development, we shape our research by following the latest scientific advances.
Our goal is to support cancer patients by offering scientifically based and safe experimental approaches beyond standard treatment options, improving their quality of life and helping them in their fight against the disease.

Innovative Research
Innovative approaches with the most up-to-date scientific methods
Ethical Standards
Patient safety and ethical rules are our priority
Technologies & Approaches
With advanced technologies and scientific approaches used in cancer research, we develop the treatment methods of the future today.
Immunomodulation
Experimental approaches that strengthen the immune system's natural defense mechanisms against cancer cells. We aim to enhance the body's own defense capacity through immune system modulation.
Genetic Approaches
Developing patient-specific treatment protocols through personalized genetic profile analysis. By considering genetic variations, we implement more effective and safer research methods.
Cellular Therapy
Experimental treatment methods targeting cancer cells with modified cellular approaches. We develop innovative research protocols with cell-based therapies.
Nanotechnology
Research on targeted drug delivery with nano-scale carrier systems. With nanotechnology-supported approaches, we develop more effective treatment options with fewer side effects.
Biomarker Analysis
Tracking disease progression and evaluating treatment response with advanced biomarker analysis techniques. We offer personalized approaches with detailed analysis at the molecular level.
Combined Protocols
Integrated approaches that combine different treatment modalities. We develop research protocols that combine multiple treatment strategies to create synergistic effects.
Our Advanced Technology Infrastructure
We support our research with state-of-the-art laboratory equipment and analysis systems. With devices capable of molecular-level analysis, our genetic sequencing systems, and our bioinformatics infrastructure, we achieve the most precise results.

Research & Clinical Studies
We open new horizons in cancer treatment with our clinical research and scientific study processes.
Our Research Process
Application Evaluation
A detailed analysis of medical history, current condition, and eligibility criteria is performed. Our multidisciplinary team carefully reviews each application.
Multidisciplinary Consultation
Comprehensive evaluation and determination of the appropriate protocol by our expert team. Oncologists, immunologists, and genetics specialists come together.
Informed Consent
Detailed information about the research process, potential risks, and benefits. Patient rights and safety are our priority.
Research Protocol
Implementation of a personalized research plan and continuous monitoring. Every stage is meticulously followed.
Follow-up & Evaluation
Regular check-ups and scientific analysis of results for continuous improvement. We have a long-term follow-up program.
Active Research Areas
Solid Tumor Research
Innovative approaches in lung, breast, colorectal, and other solid tumors. Combinations of targeted therapy and immunotherapy.
Hematologic Malignancies
Special protocols for leukemia, lymphoma, and other blood cancers. CAR-T cell therapy and hematopoietic stem cell approaches.
Pediatric Oncology
Age-appropriate experimental approaches in childhood cancers. Protocols specific to the developmental period and family support programs.
Rare Cancer Types
Specialized research protocols in less common cancer types. Orphan drug development and international collaborations.
Research Ethics
All our research is conducted in accordance with the Declaration of Helsinki and GCP (Good Clinical Practice) guidelines. Patient safety is always our priority, and ethics committee approvals have been obtained.
Our Research Statistics
Numerical data from our scientific studies



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Cutting-Edge Treatments
02
World-Class Laboratories
03
Proven Success
Introducing MST-335 immunomodulator, boasting an exceptional 85% success rate in cancer treatment, we lead the way in medical breakthroughs.
Cutting-Edge Solutions
Our Services
Explore the range of groundbreaking services offered by Masten Research.
Gene Therapy
Revolutionary treatment to modify or replace defective genes, offering hope for genetic disorder patients.
Immunomodulation
Enhancing the body’s immune response to combat diseases and improve treatment outcomes.
Chemotherapy
Advanced chemotherapy treatments tailored to individual patient needs for effective cancer management.
DNA Manipulation
Our expertise in DNA manipulation allows us to alter DNA structures, modifying gene expression patterns and unlocking new possibilities for therapeutic advancements.
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Our location
Sahrayıcedit Mah., Atatürk Cad., No:50, Kadıköy, İstanbul, TURKIYE
Opening Hours
Mon-Fri: 6am-10pm
Sat-Sun: 8am-2pm
Contact
Email: mastenclinic@gmail.com