{"id":467,"date":"2021-08-25T05:39:27","date_gmt":"2021-08-25T05:39:27","guid":{"rendered":"https:\/\/mastenresearch.com\/services\/"},"modified":"2025-09-18T08:23:30","modified_gmt":"2025-09-18T05:23:30","slug":"services","status":"publish","type":"page","link":"https:\/\/mastenresearch.com\/tr\/services\/","title":{"rendered":"Hizmetler"},"content":{"rendered":"
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Hizmetlerimiz<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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01.<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Gen Tedavisi<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tAr\u0131zal\u0131 genleri de\u011fi\u015ftirmek veya yerine koymak i\u00e7in devrim niteli\u011finde bir tedavi, genetik bozukluk hastalar\u0131na umut sunar.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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02.<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u0130mm\u00fcnomod\u00fclasyon<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tHastal\u0131klara kar\u015f\u0131 sava\u015fmak ve tedavi sonu\u00e7lar\u0131n\u0131 iyile\u015ftirmek i\u00e7in v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131n\u0131 g\u00fc\u00e7lendirme.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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03.<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Kemoterapi<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tEtkili kanser y\u00f6netimi i\u00e7in bireysel hasta ihtiya\u00e7lar\u0131na g\u00f6re uyarlanm\u0131\u015f ileri d\u00fczey kemoterapi tedavileri.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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04.<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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DNA Manip\u00fclasyonu<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tDNA manip\u00fclasyonundaki uzmanl\u0131\u011f\u0131m\u0131z sayesinde, DNA yap\u0131s\u0131n\u0131 de\u011fi\u015ftirerek gen ifadelerini modifiye ediyor ve tedavi alan\u0131nda yeni olanaklar\u0131n kap\u0131s\u0131n\u0131 aral\u0131yoruz.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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05.<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Rejeneratif Gen\u00e7le\u015ftirme<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tYa\u015flanma kar\u015f\u0131t\u0131 ara\u015ft\u0131rmalar\u0131m\u0131z kapsam\u0131nda, h\u00fccresel d\u00fczeyde ya\u015flanma s\u00fcre\u00e7lerini tersine \u00e7evirmeye y\u00f6nelik yenilik\u00e7i yakla\u015f\u0131mlar\u0131 inceliyoruz.\nBu \u00e7al\u0131\u015fmalar, sa\u011fl\u0131kl\u0131 ya\u015fam s\u00fcresinin uzat\u0131lmas\u0131 ve ya\u015fam kalitesinin art\u0131r\u0131lmas\u0131 a\u00e7\u0131s\u0131ndan \u00f6nemli kap\u0131lar aralayabilir.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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G\u00f6z At\u0131n<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Masten, ileri evre kanser tedavisi i\u00e7in geli\u015ftirilmi\u015f yeni ve etkili bir y\u00f6ntemdir.\nBu y\u00f6ntem, MST-335 adl\u0131 \u00f6zel bir molek\u00fcl ile imm\u00fcnomod\u00fclasyon ad\u0131 verilen bir s\u00fcre\u00e7ten olu\u015fur.\nMST-335, kanser h\u00fccrelerinin DNA\u2019s\u0131na zarar vererek b\u00f6l\u00fcnmelerini engeller.\n\u0130mm\u00fcnomod\u00fclasyon ise v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k sistemini g\u00fc\u00e7lendirerek, kanser h\u00fccrelerini tan\u0131mas\u0131n\u0131 ve yok etmesini sa\u011flar.
Masten tedavisi, d\u00fcnya genelinde uygulanan di\u011fer tedavilere k\u0131yasla \u00e7ok daha y\u00fcksek bir ba\u015far\u0131 oran\u0131na sahiptir.\nMasten tedavisi ile kanser hastalar\u0131n\u0131n \u2019i tamamen iyile\u015febilmektedir.\nAyr\u0131ca, Masten tedavisi az yan etkiye sahip g\u00fcvenli bir terapidir.\nMasten tedavisi, kanser hastalar\u0131 i\u00e7in bir umut \u0131\u015f\u0131\u011f\u0131d\u0131r.\n\u0130leri d\u00fczey kanser tedavisi ar\u0131yorsan\u0131z, Masten tedavisini deneyin.\nKanserle Masten ile sava\u015f\u0131n!\nMasten tedavisinin temelini olu\u015fturan MST-335 ve imm\u00fcnomod\u00fclasyon, gen terapisi y\u00f6ntemleriyle uygulanmaktad\u0131r.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Gen terapisi, insan h\u00fccrelerindeki genlerin d\u00fczenlenmesine veya hastal\u0131klar\u0131n \u00f6nlenmesine olanak tan\u0131yan bir y\u00f6ntemdir.\nAma\u00e7, mutasyona u\u011fram\u0131\u015f veya hastal\u0131\u011fa neden olan genlerin yerine uygun genlerin aktar\u0131lmas\u0131d\u0131r.
Gen terapisi \u00e7al\u0131\u015fmalar\u0131nda kar\u015f\u0131la\u015f\u0131lan en \u00f6nemli zorluklardan biri, DNA molek\u00fcllerinin hedef h\u00fccrelere aktar\u0131lmas\u0131d\u0131r ve bu s\u00fcre\u00e7 viral ya da viral olmayan vekt\u00f6rler arac\u0131l\u0131\u011f\u0131yla ger\u00e7ekle\u015ftirilir.\nViral vekt\u00f6rler, vir\u00fcslerin enfekte ettikleri h\u00fccrelere genetik materyallerini etkili bir \u015fekilde ta\u015f\u0131mas\u0131n\u0131 sa\u011flayan mekanizmalar kullan\u0131larak olu\u015fturulur.\nViral olmayan vekt\u00f6rler ise, n\u00fckleik asitler gibi \u00e7e\u015fitli terap\u00f6tik ajanlar\u0131n polimer bazl\u0131 ve inorganik biyomalzemelere eklenmesiyle sentezlenen nano boyuttaki ta\u015f\u0131y\u0131c\u0131lard\u0131r.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\t\t\tMasten tedavisinde, MST-312 molek\u00fcl\u00fc hedef h\u00fccrelere lipozom ad\u0131 verilen viral olmayan bir vekt\u00f6r ile ta\u015f\u0131n\u0131r.\nLipozomlar, DNA\u2019n\u0131n negatif y\u00fck\u00fcn\u00fc maskeleyerek, DNA molek\u00fcl\u00fcn\u00fc s\u0131k\u0131\u015ft\u0131rarak ve h\u00fccre i\u00e7i n\u00fckleaz aktivitesinden koruyarak gen aktar\u0131m\u0131n\u0131 art\u0131ran fosfolipit katmanlar\u0131ndan olu\u015fan k\u00fcresel yap\u0131lard\u0131r.\n\u0130mm\u00fcnomod\u00fclasyonda, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin \u00f6nemli bir bile\u015feni olan dendritik h\u00fccreler (DC) kullan\u0131l\u0131r.\nDendritik h\u00fccreler, v\u00fccuda giren yabanc\u0131 maddeleri tan\u0131yan ve T h\u00fccreleri gibi ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerini aktive eden antijen sunucu h\u00fccrelerdir.\nT\u00fcm\u00f6r h\u00fccreleri, DC fonksiyonunu bask\u0131layarak dendritik h\u00fccrelerin T h\u00fccrelerini aktive etmesini engeller. \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\t\t\t\u0130mm\u00fcnomod\u00fclasyon, t\u00fcm\u00f6r h\u00fccresi antijenlerini ta\u015f\u0131yan viral bir vekt\u00f6r olan adenovir\u00fcs ile dendritik h\u00fccreleri (DC) enfekte eder; bu sayede DC\u2019ler T h\u00fccrelerini aktive eder ve b\u00f6ylece t\u00fcm\u00f6r h\u00fccrelerinin yok edilmesini sa\u011flar.\nMasten tedavisi, gen terapisi ve imm\u00fcnomod\u00fclasyon gibi ileri teknolojileri kullanarak kanser hastal\u0131\u011f\u0131na kar\u015f\u0131 etkili bir \u00e7\u00f6z\u00fcm sunmaktad\u0131r.\nMasten tedavisi, kanser hastalar\u0131n\u0131n ya\u015fam kalitesini art\u0131rmakta ve gen\u00e7le\u015fmelerine katk\u0131da bulunmaktad\u0131r.\nMasten tedavisi, kanser ara\u015ft\u0131rmalar\u0131nda yeni bir d\u00f6nemin ba\u015flang\u0131c\u0131n\u0131 i\u015faret etmektedir.\n\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Gen terapisi, geleneksel tedavi y\u00f6ntemleriyle umut vaat etmeyen y\u0131k\u0131c\u0131 kal\u0131tsal hastal\u0131klar\u0131n tedavisinde b\u00fcy\u00fck potansiyele sahiptir.<\/strong> Gen terapisinin temel amac\u0131, kanser h\u00fccreleri gibi belirli h\u00fccre tiplerine yabanc\u0131 genetik materyalleri kaps\u00fclleyip ta\u015f\u0131yabilen, etkili ve toksik olmayan gen ta\u015f\u0131y\u0131c\u0131lar\u0131 geli\u015ftirmektir.\nGen terapisi, hastal\u0131\u011f\u0131n sadece belirtilerini tedavi etmek yerine, kanserin temel nedenine odaklanarak kanser tedavisinde devrim yaratma potansiyeline sahiptir.<\/p>

Gen terapisi, hastal\u0131\u011fa neden olan gen veya genlerin sa\u011fl\u0131kl\u0131 genlerle de\u011fi\u015ftirilmesi i\u015flemidir ve gen d\u00fczenleme olarak adland\u0131r\u0131l\u0131r.<\/strong> Genetik de\u011fi\u015fiklikleri hedef alan ve \"hedefe y\u00f6nelik ak\u0131ll\u0131 ila\u00e7lar\" olarak adland\u0131rd\u0131\u011f\u0131m\u0131z tedavilerde, hasarl\u0131 gen de\u011fi\u015ftirilmez; bunun yerine hasarl\u0131 gen taraf\u0131ndan \u00fcretilen h\u00fccresel \u00fcr\u00fcnlerin (resept\u00f6r, b\u00fcy\u00fcme fakt\u00f6r\u00fc vb.) \u00fcretimi engellenir.\nGen terapileri genetik hastal\u0131\u011f\u0131 tamamen ortadan kald\u0131rma potansiyeline sahipken, hedefe y\u00f6nelik ak\u0131ll\u0131 ila\u00e7lar hastal\u0131\u011f\u0131 kontrol alt\u0131na almakla s\u0131n\u0131rl\u0131d\u0131r (\u00f6rne\u011fin t\u00fcm\u00f6r\u00fcn k\u00fc\u00e7\u00fclmesi, b\u00fcy\u00fcmesinin engellenmesi gibi).<\/p>

Gen terapisi sa\u011flamak i\u00e7in farkl\u0131 y\u00f6ntemler vard\u0131r. H\u00fccre d\u0131\u015f\u0131 gen terapisi<\/strong> V\u00fccuttan al\u0131nan h\u00fccrelerin laboratuvarda genetik olarak de\u011fi\u015ftirilip tekrar hastaya verilmesini i\u00e7eren bir tedavi y\u00f6ntemidir. H\u00fccre i\u00e7i gen terapisi<\/strong> Genellikle, genetik materyalin viral veya viral olmayan vekt\u00f6rler kullan\u0131larak do\u011frudan hastan\u0131n v\u00fccuduna aktar\u0131lmas\u0131 anlam\u0131na gelir. Yerinde gen terapisi<\/strong> Hastan\u0131n v\u00fccudundaki hedef dokuya genetik materyalin do\u011frudan enjekte edilmesini ifade eder.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Kanser tedavisinde kullan\u0131lan gen terapisi \u00f6rneklerinden baz\u0131lar\u0131 \u015funlard\u0131r:<\/strong><\/p>

  • CRISPR\/CAS9 Tekni\u011fi:\nBu teknik, kanser h\u00fccrelerindeki mutasyonlar\u0131 d\u00fczeltmek veya kanserle ili\u015fkili genleri devre d\u0131\u015f\u0131 b\u0131rakmak i\u00e7in genetik kodu kesip yap\u0131\u015ft\u0131ran bir enzim kullan\u0131r.\nAkci\u011fer, meme, kan ve beyin kanseri gibi \u00e7e\u015fitli kanser t\u00fcrlerinde bu teknik \u00fczerinde \u00e7al\u0131\u015fmalar y\u00fcr\u00fct\u00fclmektedir.<\/p><\/li>

  • Talimogene Laherparepvec (T-VEC):\nBu tedavi, genetik olarak de\u011fi\u015ftirilmi\u015f bir herpes vir\u00fcs\u00fcn\u00fc kullanarak kanser h\u00fccrelerini enfekte eder ve yok eder.\nMalign melanom (cilt kanseri) tedavisi i\u00e7in geli\u015ftirilmi\u015f olup, FDA taraf\u0131ndan onaylanm\u0131\u015ft\u0131r.<\/p><\/li>

  • Larotrectinib:\nBu ila\u00e7, TRK f\u00fczyonu ad\u0131 verilen genetik de\u011fi\u015fikli\u011fi hedef al\u0131r.\nBu de\u011fi\u015fiklik, kanser h\u00fccrelerinin kontrols\u00fcz \u015fekilde \u00e7o\u011falmas\u0131na neden olur.\n\u0130la\u00e7, 2017 y\u0131l\u0131nda FDA onay\u0131 alm\u0131\u015f olup, \u00e7e\u015fitli kanser t\u00fcrlerinde etkili oldu\u011fu kan\u0131tlanm\u0131\u015ft\u0131r.<\/p><\/li>

  • MST-312-335-337:\nBu y\u00f6ntem, kanser h\u00fccrelerinin b\u00f6l\u00fcnmesini engellemek i\u00e7in DNA\u2019s\u0131na zarar veren MST-312 adl\u0131 bir molek\u00fcl\u00fc kullan\u0131r.\nMST-312, lipozom ad\u0131 verilen k\u00fcresel yap\u0131lar ile hedef h\u00fccrelere ta\u015f\u0131n\u0131r.\nMST-312, kanser h\u00fccrelerinin b\u00fcy\u00fcmesini ve yay\u0131lmas\u0131n\u0131 durdurur.<\/p><\/li>

  • \u0130mm\u00fcnomod\u00fclasyon<\/strong> Bu y\u00f6ntem, ba\u011f\u0131\u015f\u0131kl\u0131k sistemini g\u00fc\u00e7lendiren **imm\u00fcnomod\u00fclasyon** adl\u0131 bir s\u00fcre\u00e7 kullan\u0131r. \u0130mm\u00fcnomod\u00fclasyon, t\u00fcm\u00f6r h\u00fccrelerinin antijenlerini ta\u015f\u0131yan bir adenovir\u00fcs ile **dendritik h\u00fccreleri** enfekte eder. Dendritik h\u00fccreler, antijen sunan h\u00fccrelerdir ve **T h\u00fccreleri** gibi ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerini aktive eder. \u0130mm\u00fcnomod\u00fclasyon, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin kanser h\u00fccrelerini tan\u0131mas\u0131n\u0131 ve yok etmesini sa\u011flar.<\/p><\/li>

  • Gen Terapisi:\nBu y\u00f6ntem, insan h\u00fccrelerindeki genlerin d\u00fczenlenmesine veya hastal\u0131klar\u0131n \u00f6nlenmesine olanak tan\u0131yan gen terapisi tekni\u011fini kullan\u0131r.\nGen terapisinde ama\u00e7, mutasyona u\u011fram\u0131\u015f veya hastal\u0131\u011fa neden olan genlerin yerine uygun genlerin aktar\u0131lmas\u0131d\u0131r.\nGen terapisi, DNA molek\u00fcllerinin viral veya viral olmayan vekt\u00f6rler arac\u0131l\u0131\u011f\u0131yla hedef h\u00fccrelere ta\u015f\u0131nmas\u0131n\u0131 kolayla\u015ft\u0131r\u0131r.<\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

    \n\t\t\t\t<\/div>\n\t\t
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    Masten, ileri evre kanser tedavisi i\u00e7in geli\u015ftirilmi\u015f yeni ve etkili bir y\u00f6ntemdir.<\/strong> Masten, MST-312 adl\u0131 bir molek\u00fcl ve imm\u00fcnomod\u00fclasyon ad\u0131 verilen bir s\u00fcre\u00e7ten olu\u015fur.<\/p>

    • Masten tedavisi ile kanser hastalar\u0131n\u0131n \u2019i tamamen iyile\u015ftirilebilir.<\/p><\/li>

    • Masten tedavisi, az yan etkiye sahip g\u00fcvenli bir terapidir.<\/p><\/li>

    • Masten tedavisi, gen terapisi ve imm\u00fcnomod\u00fclasyon gibi ileri teknolojileri kullanarak kanser hastal\u0131\u011f\u0131na kar\u015f\u0131 etkili bir \u00e7\u00f6z\u00fcm sunar.<\/p><\/li>

    • Masten tedavisi, kanser hastalar\u0131n\u0131n ya\u015fam kalitesini art\u0131r\u0131r ve gen\u00e7le\u015fmelerine katk\u0131da bulunur.<\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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      Masten tedavisi i\u00e7in ba\u015fvuruda bulunmak \u00fczere l\u00fctfen a\u015fa\u011f\u0131daki formu doldurunuz. Ba\u015fvurunuz g\u00f6nderildikten sonra en k\u0131sa s\u00fcrede sizinle ileti\u015fime ge\u00e7ilecektir.<\/p>

      Masten tedavisi i\u00e7in uygun olabilmek ad\u0131na ba\u015fvuru sahiplerinin a\u015fa\u011f\u0131daki \u015fartlar\u0131 kar\u015f\u0131lamas\u0131 gerekmektedir:<\/p>

      • 18 ya\u015f\u0131ndan b\u00fcy\u00fck olmak.<\/li>
      • \u0130leri evre kanser tan\u0131s\u0131 alm\u0131\u015f olmak.<\/li>
      • Ba\u015fka bir kanser tedavisi g\u00f6rm\u00fcyor olmak.<\/li>
      • Masten tedavisi i\u00e7in uygunlu\u011funuzu onaylayan bir doktor raporu sunmak.<\/li>
      • Kanserin t\u00fcr\u00fcn\u00fc, evresini ve tedavi ge\u00e7mi\u015fini belgeleyebilmek.<\/li>
      • Kanser tedavisinin yan etkileri ve komplikasyonlar\u0131yla ba\u015fa \u00e7\u0131kabilmek i\u00e7in gerekti\u011finde psikolojik deste\u011fe eri\u015fimi olmak.<\/li>
      • Tedavinin etkinli\u011fini ve g\u00fcvenli\u011fini de\u011ferlendirmek amac\u0131yla gerekli test, muayene ve kontrolleri kabul etmek.<\/li>
      • Tedavinin amac\u0131, s\u00fcreci, riskleri ve faydalar\u0131n\u0131 a\u00e7\u0131klayan bilgilendirilmi\u015f onam formunu imzalamak.<\/li><\/ul>

        E\u011fer bu \u015fartlar\u0131 kar\u015f\u0131l\u0131yor ve Masten ara\u015ft\u0131rmas\u0131na ba\u015fvurmakla ilgileniyorsan\u0131z, l\u00fctfen [ba\u015fvuru formunu] doldurunuz. Ba\u015fvurunuz de\u011ferlendirildikten sonra sizinle ileti\u015fime ge\u00e7ilecektir.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

        \n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

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